Formulasi Nanoemulgel Ekstrak Biji Kopi Robusta (Coffea canephora Pierre) Dengan Variasi Gelling Agent Sebagai Antioksidan
نویسندگان
چکیده
Antioksidan merupakan suatu senyawa yang berperan penting dalam mekanisme pertahanan tubuh melawan radikal bebas yaitu menghambat reaksi oksidatif. Salah satu bahan alam memiliki aktivitas antioksidan biji kopi robusta. Biji robusta diketahui mengandung polifenol sebagai antioksidan. Nanooemulgel sediaan gel diinkorporasikan basis dan partikel berukuran nano. Penelitian ini bertujuan untuk 1) mengetahui formula stabil nanoemulgel ekstrak dengan variasi gelling agent 2) apakah antioksidan.
 Metode digunakan meliputi ekstraksi dilakukan maserasi nanoemulsi dibuat menggunakan teknik kinerja rendah (magnetic stirrer) tinggi (sonicator) 3) uji ukuran dynamic light scattering 4) parameter stabilitas pH, daya sebar, lekat viskositas 5) dianalisis metode DPPH (1,1-diphenyl-2-picrilhidrazyl) 6) analisis secara statistik software SPSS 21 Paired T-test One Way Anova.
 Hasil sebesar 12,3 nm indeks polidispersitas 0,274 nm, paling 3 konsentrasi (1 gram HPMC : 0,5 Carbopol ) nilai rata-rata pH 5 ± 0, rata- rata (1,59 0,01) detik, sebar (6,7 0,1) cm , (2500 0)cPs. Formula kuat 1 (0,5 carbopol) IC50 (10,678 0,034) ppm
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ژورنال
عنوان ژورنال: Jurnal Farmasi Indonesia
سال: 2023
ISSN: ['1693-8615', '2302-4291']
DOI: https://doi.org/10.31001/jfi.v20i1.1518